Collateral sensitivity of antibiotic-resistant microbes
نویسندگان
چکیده
منابع مشابه
Collateral sensitivity to methotrexate in cells resistant to adriamycin.
Chinese hamster ovary (CHO) cells, maintained and treated in log-phase growth, are extremely sensitive to Adniamycin but are very resistant to methotrexate-induced cell killing. The survival response to Adniamycin is biphasic, with the sensitive population showing a D0 of 0.08 pg/mI for 1 hr, while essen tially no cell killing is produced by methotrexate treatments of up to 500 @.tg/mI for eith...
متن کاملAntibiotic Sensitivity and Clinical Outcome for Methicillin Resistant Staphylococcus Aureus
and reproduction in any medium, provided the original work is properly cited.
متن کاملNovel benzoxazoles: synthesis and antibacterial, antifungal, and antitubercular activity against antibiotic-resistant and -sensitive microbes.
A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis as well as against Candida a...
متن کاملCollateral sensitivity of 2 receptor ligands: potentials in the treatment of multidrug resistant tumors
Tumors are one of the main causes of human illnesses and death with MultiDrug Resistance (MDR) being the most severe limitation to the success of chemotherapy. MDR is mainly due to the overexpression of drug efflux transporters, such as P-glycoprotein (P-gp), but attempts to inhibit P-gp have not been clinically successful so far. Lately, some agents were found to be more effective against P-gp...
متن کاملCollateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
Certain N-alkylated analogues of the natural polyamine spermine, such as N1,N11-diethylnorspermine (DENSPM), rapidly deplete intracellular polyamine pools by down-regulating the biosynthetic enzymes, ornithine decarboxylase and S-adenosylmethionine decarboxylase, and by potently up-regulating the polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase. On the basis of previously...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Microbiology
سال: 2015
ISSN: 0966-842X
DOI: 10.1016/j.tim.2015.02.009